NAALAD2

Across TCGA patient cohorts, NAALAD2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAALAD2-associated genes across cancer lineages are PCNA, TFRC, and Cyclin-B1. Each is linked with NAALAD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NAALAD2-to-partner and partner-to-NAALAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NAALAD2-low versus NAALAD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALAD2→partner) and Y-score (partner→NAALAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.169	+1.925	.012	.004	3	4
UCEC	TFRC →	+0.451	+3.807	.006	<.001	3	3
UCEC	Cyclin-B1 →	+0.572	+2.169	.001	.003	3	3
UCEC	GATA6 →	-0.121	-1.770	.014	.002	3	2
UCEC	Notch1 →	+0.111	+1.450	.012	.014	3	2
UCEC	PDCD4 →	-0.416	-1.668	.005	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PCNA by NAALAD2 expression — UCEC

Explore this box plot interactively →