NAALAD2

Across TCGA cell cohorts, NAALAD2 mutation is significantly associated with the RNA expression of many other genes, with 360 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NAALAD2-associated genes across cancer lineages are CHIA, COX6A2, and PRR20G. Each is linked with NAALAD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAALAD2-to-partner and partner-to-NAALAD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHIA grouped by NAALAD2-low versus NAALAD2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAALAD2→partner) and Y-score (partner→NAALAD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CHIA →	+0.024	+3.475	<.001	.006	3	2
BLOOD_Leukemia	COX6A2 →	+0.379	+3.684	<.001	.004	3	2
LUNG_NSCLC_LUAD	PRR20G →	+0.429	+3.307	<.001	.008	3	2
BLOOD_Lymphoma	HTR1A →	+0.016	+4.643	<.001	.005	3	1
LUNG_SCLC	NOX3 →	+0.159	+3.669	.009	.008	3	1
LARGE_INTESTINE	EIF3L →	+0.522	+3.067	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 360 associations by consensus.

CHIA by NAALAD2 expression — BLOOD_Leukemia

Explore this box plot interactively →