NAAA

Across TCGA pan-cancer cohorts, NAAA Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAAA data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher NAAA Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NAAA expression acts as an unfavorable survival marker, although some lineages such as ESCA show a favorable association.

SCLC, DLBC, and UCEC are the cancer types where NAAA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.301	0.711	.018	15	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
THCA	OS	Median	All	0.342	0.955	<.001	3	view →
ESCA	OS	Median	All	1.000	0.443	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAAA–SCLC (OS)

Open the SCLC breakdown →