NAAA

Across TCGA pan-cancer cohorts, NAAA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NAAA data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NAAA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NAAA expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, GBM, and HNSC are the cancer types where NAAA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.887	0.283	.012	21	view →
GBM	OS	Median	All	0.721	0.895	<.001	16	view →
HNSC	DFS	Median	III,IV	0.502	0.771	.010	14	view →
LUAD	DFS	Quartile	III,IV	0.302	0.944	.006	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NAAA–CCRCC (DFS)

Open the CCRCC breakdown →