NAAA

Across TCGA pan-cancer cohorts, NAAA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NAAA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where NAAA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NAAA is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and LSCC are the cancer types where NAAA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAAA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.738	<.001	9	view →
COAD	Female	III,IV	−0.431	<.001	9	view →
LSCC	All	III,IV	−0.979	<.001	8	view →
PDAC	All	IV	−0.363	.041	1	view →
HNSC	Male	III,IV	−0.222	.007	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NAAA–LUAD

Open the LUAD breakdown →