NAAA

Across TCGA patient cohorts, NAAA mutation is significantly associated with the RNA expression of many other genes, with 2,742 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAAA-associated genes across cancer lineages are RNA5SP62, RNA5SP176, and MIR1263. Each is linked with NAAA in more than 1 cancer types. Because this analysis shows association rather than direction, both NAAA-to-partner and partner-to-NAAA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP62 grouped by NAAA-low versus NAAA-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAAA→partner) and Y-score (partner→NAAA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP62 →	+0.906	+5.105	<.001	.008	3	2
STAD	RNA5SP176 →	+1.212	+5.463	<.001	.005	3	2
STAD	MIR1263 →	+1.396	+5.798	<.001	.003	3	2
STAD	RNA5SP458 →	+0.646	+5.026	<.001	.009	3	2
STAD	RNA5SP228 →	+0.926	+5.026	<.001	.009	3	2
STAD	RNU6-965P →	+0.520	+5.274	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,742 associations by consensus.

RNA5SP62 by NAAA expression — STAD

Explore this box plot interactively →