NAA60

Across TCGA patient cohorts, NAA60 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAA60-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and Ku80. Each is linked with NAA60 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAA60-to-partner and partner-to-NAA60 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by NAA60-low versus NAA60-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAA60→partner) and Y-score (partner→NAA60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.207	+3.169	.021	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.143	-2.312	.013	.034	3	1
UCEC	Ku80 →	+0.216	+1.887	.049	.031	3	1
UCEC	MEK1 →	+0.359	+2.584	.035	.011	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.494	-3.169	.018	.019	3	1
UCEC	PCNA →	+0.291	+2.584	.003	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

ERK2 by NAA60 expression — UCEC

Explore this box plot interactively →