NAA50

Across TCGA patient cohorts, NAA50 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAA50-associated genes across cancer lineages are Notch1, EGFR_pY1068, and A-Raf_pS299. Each is linked with NAA50 in more than 1 cancer types. Because this analysis shows association rather than direction, both NAA50-to-partner and partner-to-NAA50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NAA50-low versus NAA50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAA50→partner) and Y-score (partner→NAA50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.189	+2.469	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.258	-3.906	.018	<.001	3	1
UCEC	A-Raf_pS299 →	-0.174	-3.459	<.001	.005	3	1
UCEC	INPP4B →	-0.287	-2.999	.042	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.199	-3.321	.006	.009	3	1
UCEC	JNK2 →	+0.207	+2.179	.017	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Notch1 by NAA50 expression — UCEC

Explore this box plot interactively →