NAA50

Across TCGA cell cohorts, NAA50 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,178 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NAA50-associated GO terms across cancer lineages are tRNA wobble guanine modification, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Double-strand break repair via nonhomologous end joining. Each is linked with NAA50 in more than 14 cancer types. Because this analysis shows association rather than direction, both NAA50-to-partner and partner-to-NAA50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, tRNA wobble guanine modification grouped by NAA50-low versus NAA50-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NAA50→partner) and Y-score (partner→NAA50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	tRNA wobble guanine modification →	+0.171	+1.074	<.001	<.001	3	15
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.109	+0.931	.002	.001	3	15
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via nonhomologous end joining →	+0.063	+1.159	<.001	<.001	3	15
BLOOD_Myeloma	rRNA 5'-end processing →	+0.109	+0.931	.002	.001	3	15
BLOOD_Myeloma	Negative regulation of cell cycle process →	+0.074	+1.341	<.001	<.001	3	14
LIVER	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.122	+1.022	.005	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,178 associations by consensus.

tRNA wobble guanine modification by NAA50 expression — SOFT_TISSUE

Explore this box plot interactively →