NAA40

Across TCGA pan-cancer cohorts, NAA40 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NAA40 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NAA40 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NAA40 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LUAD, HNSC, and CCRCC are the cancer types where NAA40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.890	.004	28	view →
HNSC	DFS	Median	II,III,IV	0.750	0.509	.002	26	view →
CCRCC	DFS	Median	III,IV	0.671	0.958	.003	16	view →
PDAC	DFS	Quartile	II,III,IV	0.480	0.308	.031	8	view →
UCEC	DFS	Tertile	III,IV	1.000	0.529	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NAA40–LUAD (OS)

Open the LUAD breakdown →