NAA35

Across TCGA pan-cancer cohorts, NAA35 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NAA35’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NAA35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NAA35 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where NAA35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NAA35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.804	<.001	10	view →
THCA	All	II,III,IV	−0.537	<.001	9	view →
LIHC	All	All	+0.492	<.001	8	view →
BRCA	All	II,III,IV	+0.333	<.001	8	view →
LUAD	Male	II,III,IV	+0.706	<.001	7	view →
KIRC	Male	III,IV	−0.582	<.001	7	view →
LUSC	Female	All	+0.797	<.001	6	view →
STAD	All	All	+0.582	<.001	6	view →
BLCA	All	III,IV	+0.611	.001	5	view →
CHOL	All	All	+1.310	<.001	4	view →
UCEC	All	III,IV	+1.078	.003	4	view →
ESCA	All	All	+0.688	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NAA35–HNSC

Open the HNSC breakdown →