NAA25

Across TCGA pan-cancer cohorts, NAA25 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NAA25 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NAA25 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NAA25 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where NAA25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.706	0.952	<.001	91	view →
LSCC	DFS	Tertile	All	1.000	0.861	<.001	48	view →
PDAC	OS	Quartile	All	0.348	0.735	<.001	44	view →
LUAD	DFS	Tertile	All	0.481	1.000	.007	18	view →
UCEC	OS	Quartile	III,IV	1.000	0.345	.021	12	view →
HNSC	OS	Median	All	1.000	0.959	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NAA25–CCRCC (OS)

Open the CCRCC breakdown →