NAA11

Across TCGA patient cohorts, NAA11 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NAA11-associated genes across cancer lineages are PDCD4, MEK1, and eIF4E. Each is linked with NAA11 in more than 2 cancer types. Because this analysis shows association rather than direction, both NAA11-to-partner and partner-to-NAA11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by NAA11-low versus NAA11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NAA11→partner) and Y-score (partner→NAA11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.649	-2.000	.002	.032	3	3
UCEC	MEK1 →	+0.358	+2.321	.029	.034	3	2
SKCM	eIF4E →	+0.208	+2.459	.014	.020	2	3
UCEC	eEF2 →	+0.510	+2.700	.001	.006	3	1
UCEC	ERK2 →	+0.246	+3.169	.004	.018	3	1
UCEC	FoxM1 →	+0.338	+2.700	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

PDCD4 by NAA11 expression — UCEC

Explore this box plot interactively →