N4BP2L1

Across TCGA patient cohorts, N4BP2L1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible N4BP2L1-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with N4BP2L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both N4BP2L1-to-partner and partner-to-N4BP2L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by N4BP2L1-low versus N4BP2L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (N4BP2L1→partner) and Y-score (partner→N4BP2L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.237	+2.807	.006	.003	3	1
UCEC	Ku80 →	+0.206	+1.598	.045	.044	3	1
UCEC	MEK1 →	+0.503	+3.584	.001	.002	3	1
UCEC	PAI-1 →	+0.337	+2.584	.024	.010	3	1
UCEC	PDCD4 →	-0.622	-2.575	.002	.010	3	1
UCEC	VHL →	-0.672	-2.584	.023	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK2 by N4BP2L1 expression — UCEC

Explore this box plot interactively →