N4BP2

Across TCGA cell cohorts, N4BP2 mutation is significantly associated with the RNA expression of many other genes, with 800 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible N4BP2-associated genes across cancer lineages are ZIM3, TDRD5, and CBY1. Each is linked with N4BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both N4BP2-to-partner and partner-to-N4BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIM3 grouped by N4BP2-low versus N4BP2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (N4BP2→partner) and Y-score (partner→N4BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ZIM3 →	+0.043	+4.643	<.001	.008	3	2
BLOOD_Lymphoma	TDRD5 →	+0.351	+2.754	<.001	.009	3	2
LARGE_INTESTINE	CBY1 →	+0.613	+2.860	<.001	<.001	3	2
LARGE_INTESTINE	JOSD1 →	+0.517	+3.459	.001	<.001	3	2
LARGE_INTESTINE	C12orf57 →	+0.787	+3.252	<.001	.002	3	2
LARGE_INTESTINE	RIC8B →	+0.429	+2.458	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 800 associations by consensus.

ZIM3 by N4BP2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →