N4BP1

Across TCGA pan-cancer cohorts, N4BP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated N4BP1 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher N4BP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated N4BP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where N4BP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	1.000	0.292	.008	18	view →
PDAC	OS	Tertile	II,III,IV	0.762	0.946	.013	5	view →
GBM	DFS	Quartile	All	0.474	0.256	.049	2	view →
CCRCC	DFS	Median	All	0.866	0.965	.042	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

N4BP1–HNSC (DFS)

Open the HNSC breakdown →