Across TCGA pan-cancer cohorts, MZT1P1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MZT1P1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MZT1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MZT1P1 is over-expressed in tumor.
HNSC, COAD, and BRCA are the cancer types where MZT1P1 tumor–normal differential expression is most reproducible.