MZF1

Across TCGA cell cohorts, MZF1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MZF1-associated genes across cancer lineages are OR5D14, NCR1, and ACSM2B. Each is linked with MZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MZF1-to-partner and partner-to-MZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5D14 grouped by MZF1-low versus MZF1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MZF1→partner) and Y-score (partner→MZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR5D14 →	+0.033	+4.906	<.001	.006	3	1
OESOPHAGUS	NCR1 →	+0.276	+4.906	<.001	.006	3	1
OESOPHAGUS	ACSM2B →	+0.080	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BREAST	LCE3D →	+1.190	+4.064	<.001	.003	3	1
BREAST	OR2J2 →	+0.014	+3.672	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

OR5D14 by MZF1 expression — OESOPHAGUS

Explore this box plot interactively →