MYZAP

Across TCGA patient cohorts, MYZAP mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYZAP-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and ASNS. Each is linked with MYZAP in more than 1 cancer types. Because this analysis shows association rather than direction, both MYZAP-to-partner and partner-to-MYZAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MYZAP-low versus MYZAP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYZAP→partner) and Y-score (partner→MYZAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.265	-2.502	.007	.002	3	2
UCEC	PDCD4 →	-0.463	-2.105	.012	.017	3	2
UCEC	ASNS →	+0.417	+2.321	.003	.033	3	2
UCEC	eIF4E →	+0.178	+2.584	.031	.010	3	1
UCEC	ERK2 →	+0.189	+2.502	.012	.002	3	1
UCEC	JNK2 →	+0.188	+1.584	.015	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by MYZAP expression — UCEC

Explore this box plot interactively →