Across TCGA patient cohorts, MYT1 mutation is significantly associated with the RNA expression of many other genes, with 2,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYT1-associated genes across cancer lineages are BUB3, CENPN, and NEK2. Each is linked with MYT1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYT1-to-partner and partner-to-MYT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYT1→partner) and Y-score (partner→MYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.243	+1.245	.007	.008	3	4
UCEC	CENPN →	+0.482	+1.413	<.001	<.001	3	4
LUAD	NEK2 →	+0.869	+2.321	.003	.006	3	4
LUAD	NUSAP1 →	+0.779	+2.321	.002	.006	3	4
UCEC	XPNPEP1 →	+0.281	+1.152	.002	.003	3	4
UCEC	CCNB1 →	+0.395	+1.392	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,870 associations by consensus.

Exploration

MYT1 survival (RNA) · tumor vs normal (RNA) · all MYT1 data types