Across TCGA cell cohorts, MYT1 mutation is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MYT1-associated genes across cancer lineages are SYT10, IQCF3, and TPD52L3. Each is linked with MYT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYT1-to-partner and partner-to-MYT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYT1→partner) and Y-score (partner→MYT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SYT10 →	+0.174	+2.632	.006	.002	3	2
LUNG_NSCLC_LUAD	IQCF3 →	+0.020	+3.006	<.001	.005	3	2
LARGE_INTESTINE	TPD52L3 →	+0.027	+2.777	.002	.004	3	2
BLOOD_Leukemia	OR1L4 →	+0.039	+2.982	<.001	.007	3	2
LUNG_NSCLC_LUSC	PLA2G2E →	+0.080	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	KRTAP10-9 →	+0.152	+4.108	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

Exploration

MYT1 survival (RNA) · tumor vs normal (RNA) · all MYT1 data types