MYRIP

Across TCGA patient cohorts, MYRIP mutation is significantly associated with the RNA expression of many other genes, with 4,939 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYRIP-associated genes across cancer lineages are C4orf46, TUBGCP5, and IGHD5-12. Each is linked with MYRIP in more than 3 cancer types. Because this analysis shows association rather than direction, both MYRIP-to-partner and partner-to-MYRIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4orf46 grouped by MYRIP-low versus MYRIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYRIP→partner) and Y-score (partner→MYRIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C4orf46 →	+0.607	+1.975	<.001	<.001	3	4
SKCM	TUBGCP5 →	+0.396	+1.722	.004	.002	3	3
READ	IGHD5-12 →	+1.287	+4.421	<.001	.009	3	3
COAD	ARRDC3-AS1 →	+0.393	+3.382	<.001	.004	3	3
UCEC	TMEM269 →	+0.166	+2.224	<.001	<.001	3	3
SKCM	LINC02340 →	+0.318	+1.504	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,939 associations by consensus.

C4orf46 by MYRIP expression — UCEC

Explore this box plot interactively →