MYOZ3

Across TCGA cell cohorts, MYOZ3 mutation is significantly associated with the mutation status of many other genes, with 1,022 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYOZ3-associated genes across cancer lineages are RGS4, UBN1, and A1BG. Each is linked with MYOZ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOZ3-to-partner and partner-to-MYOZ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGS4 grouped by MYOZ3-low versus MYOZ3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOZ3→partner) and Y-score (partner→MYOZ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RGS4 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	UBN1 →	+3.309	+4.794	.002	.002	1	2
BLOOD_Leukemia	A1BG →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	ARFGEF2 →	+3.672	+5.083	.001	.001	1	2
BLOOD_Leukemia	PKDREJ →	+3.479	+4.932	.002	.002	1	2
BLOOD_Leukemia	LPIN3 →	+4.309	+4.560	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,022 associations by consensus.

RGS4 by MYOZ3 expression — BLOOD_Leukemia

Explore this box plot interactively →