MYOZ2

Across TCGA patient cohorts, MYOZ2 mutation is significantly associated with the RNA expression of many other genes, with 137 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MYOZ2-associated genes across cancer lineages are RNU6-6P, PPP2R2B-IT1, and MRGPRX9P. Each is linked with MYOZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOZ2-to-partner and partner-to-MYOZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-6P grouped by MYOZ2-low versus MYOZ2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOZ2→partner) and Y-score (partner→MYOZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-6P →	+0.900	+3.299	<.001	.001	3	2
UCEC	PPP2R2B-IT1 →	+0.067	+4.437	.006	.005	3	2
SKCM	MRGPRX9P →	+0.046	+3.913	<.001	.001	3	2
SKCM	OR4B2P →	+0.026	+3.913	<.001	.001	3	2
SKCM	FAM72C →	+0.389	+3.366	.001	.005	3	2
SKCM	COQ2 →	+0.535	+3.328	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 137 associations by consensus.

RNU6-6P by MYOZ2 expression — UCEC

Explore this box plot interactively →