MYOZ1

Across TCGA patient cohorts, MYOZ1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MYOZ1-associated genes across cancer lineages are PRDX1, Chk2_pT68, and Annexin-1. Each is linked with MYOZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOZ1-to-partner and partner-to-MYOZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by MYOZ1-low versus MYOZ1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOZ1→partner) and Y-score (partner→MYOZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PRDX1 →	+0.373	+3.000	.026	.036	3	1
SKCM	Chk2_pT68 →	+0.196	+3.000	.028	.036	3	1
UCEC	Annexin-1 →	+0.716	+3.019	.013	.019	3	1
UCEC	4E-BP1 →	+0.416	+3.169	.005	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.584	-3.156	.018	.020	1	2
SKCM	PDCD4 →	-0.533	-3.000	.020	.036	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PRDX1 by MYOZ1 expression — SKCM

Explore this box plot interactively →