MYOT

Across TCGA patient cohorts, MYOT mutation is significantly associated with the RNA expression of many other genes, with 2,941 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOT-associated genes across cancer lineages are MIR4710, IGLJ5, and RNU6-660P. Each is linked with MYOT in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOT-to-partner and partner-to-MYOT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4710 grouped by MYOT-low versus MYOT-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOT→partner) and Y-score (partner→MYOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4710 →	+0.847	+5.337	<.001	<.001	3	3
LUAD	IGLJ5 →	+0.692	+5.410	<.001	.005	3	3
LUSC	RNU6-660P →	+0.285	+4.906	<.001	.003	3	3
LUSC	RNU4-27P →	+0.448	+4.625	<.001	<.001	3	3
LUSC	RN7SKP19 →	+0.313	+5.593	<.001	.001	3	3
HNSC	OR5AN1 →	+0.048	+6.468	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,941 associations by consensus.

MIR4710 by MYOT expression — LUSC

Explore this box plot interactively →