MYOT

Across TCGA cell cohorts, MYOT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYOT-associated genes across cancer lineages are H2BC3, OR6Q1, and RXFP1. Each is linked with MYOT in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOT-to-partner and partner-to-MYOT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC3 grouped by MYOT-low versus MYOT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOT→partner) and Y-score (partner→MYOT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BC3 →	+0.179	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	RXFP1 →	+0.201	+3.453	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

H2BC3 by MYOT expression — LARGE_INTESTINE

Explore this box plot interactively →