MYOSLID

Across TCGA pan-cancer cohorts, MYOSLID RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MYOSLID’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MYOSLID RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYOSLID is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

HNSC, LUAD, and LUSC are the cancer types where MYOSLID tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MYOSLID RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+2.381	<.001	12	view →
LUAD	All	III,IV	+1.855	<.001	9	view →
LUSC	Male	All	+1.912	<.001	7	view →
BRCA	Female	All	−0.470	<.001	6	view →
KIRC	Male	All	+0.349	<.001	6	view →
COAD	All	II,III,IV	+0.245	<.001	6	view →
BLCA	All	All	+0.812	.013	5	view →
STAD	Female	All	+0.314	.021	4	view →
THCA	All	All	+0.245	<.001	4	view →
LIHC	Male	All	+0.084	<.001	4	view →
KIRP	All	All	+0.118	.026	3	view →
PRAD	All	All	−0.174	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MYOSLID–HNSC

Open the HNSC breakdown →