MYORG

Across TCGA cell cohorts, MYORG mutation is significantly associated with the mutation status of many other genes, with 5,695 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYORG-associated genes across cancer lineages are KMT2B, TRIP11, and SRRM2. Each is linked with MYORG in more than 4 cancer types. Because this analysis shows association rather than direction, both MYORG-to-partner and partner-to-MYORG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT2B grouped by MYORG-low versus MYORG-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYORG→partner) and Y-score (partner→MYORG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	KMT2B →	+3.862	+4.347	.001	.001	1	5
BLOOD_Leukemia	TRIP11 →	+2.847	+2.498	.002	.002	1	5
BLOOD_Leukemia	SRRM2 →	+2.558	+2.949	<.001	<.001	1	5
OVARY	TRPM4 →	+3.103	+2.777	.004	.004	1	5
LARGE_INTESTINE	FAT1 →	+1.809	+2.611	<.001	<.001	1	5
UPPER_AERODIGESTIVE_TRACT	GRIN3B →	+4.392	+4.954	.008	.008	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,695 associations by consensus.

KMT2B by MYORG expression — CNS

Explore this box plot interactively →