MYOM2

Across TCGA patient cohorts, MYOM2 mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOM2-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Kit, and Cyclin-B1. Each is linked with MYOM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYOM2-to-partner and partner-to-MYOM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MYOM2-low versus MYOM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOM2→partner) and Y-score (partner→MYOM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.882	+2.008	.001	.005	3	5
COAD	c-Kit →	-0.453	-1.700	.033	.040	3	4
UCEC	Cyclin-B1 →	+0.505	+1.321	<.001	<.001	3	4
BRCA	Annexin_VII →	-0.172	-3.169	.041	.020	3	4
UCEC	Shc_pY317 →	-0.127	-1.321	<.001	.004	3	4
COAD	Bad_pS112 →	-0.232	-2.442	<.001	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

Caspase-7-cleavedD198 by MYOM2 expression — COAD

Explore this box plot interactively →