MYOM1

Across TCGA patient cohorts, MYOM1 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOM1-associated genes across cancer lineages are p38-MAPK_pT180_Y182, JNK_pT183_Y185, and 4E-BP1_pT70. Each is linked with MYOM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOM1-to-partner and partner-to-MYOM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by MYOM1-low versus MYOM1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOM1→partner) and Y-score (partner→MYOM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	p38-MAPK_pT180_Y182 →	-0.483	-3.169	.020	.019	3	3
UCEC	JNK_pT183_Y185 →	-0.099	-1.184	.018	.019	3	3
SKCM	4E-BP1_pT70 →	+0.129	+1.602	.025	.018	3	3
UCEC	GSK-3_pS9 →	-0.258	-1.125	.010	.025	3	3
UCEC	MEK1 →	+0.266	+1.632	.003	<.001	3	3
UCEC	ATM →	-0.425	-1.702	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

p38-MAPK_pT180_Y182 by MYOM1 expression — BLCA

Explore this box plot interactively →