MYOF

Across TCGA patient cohorts, MYOF mutation is significantly associated with the RNA expression of many other genes, with 4,709 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOF-associated genes across cancer lineages are GOT1, NDUFA6, and ECHS1. Each is linked with MYOF in more than 4 cancer types. Because this analysis shows association rather than direction, both MYOF-to-partner and partner-to-MYOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by MYOF-low versus MYOF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOF→partner) and Y-score (partner→MYOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GOT1 →	+0.318	+1.327	<.001	.001	3	5
STAD	NDUFA6 →	+0.503	+3.584	<.001	.002	3	4
STAD	ECHS1 →	+0.557	+3.186	.001	.009	3	4
UCEC	EMC7 →	+0.259	+1.295	.001	.001	3	4
UCEC	POU2F3 →	-0.282	-1.576	.006	<.001	3	4
UCEC	CISD2 →	+0.315	+1.386	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,709 associations by consensus.

GOT1 by MYOF expression — UCEC

Explore this box plot interactively →