MYOF

Across TCGA patient cohorts, MYOF mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOF-associated genes across cancer lineages are 4E-BP1, Cyclin-E2, and Rb_pS807_S811. Each is linked with MYOF in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOF-to-partner and partner-to-MYOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYOF-low versus MYOF-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOF→partner) and Y-score (partner→MYOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.347	+3.000	.025	.036	3	3
STAD	Cyclin-E2 →	+0.147	+3.021	.036	.018	3	3
SKCM	Rb_pS807_S811 →	+0.328	+2.321	.039	.033	3	3
UCEC	ASNS →	+0.244	+1.000	.015	.033	3	3
UCEC	ATM →	-0.413	-1.157	.001	.014	3	3
UCEC	C-Raf →	+0.084	+1.152	.035	.048	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

4E-BP1 by MYOF expression — STAD

Explore this box plot interactively →