MYOF

Across TCGA cell cohorts, MYOF mutation is significantly associated with the RNA expression of many other genes, with 848 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYOF-associated genes across cancer lineages are HAUS2, FAM25C, and OR8B8. Each is linked with MYOF in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOF-to-partner and partner-to-MYOF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS2 grouped by MYOF-low versus MYOF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOF→partner) and Y-score (partner→MYOF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HAUS2 →	+0.453	+3.169	.002	.006	3	3
OVARY	FAM25C →	+0.991	+3.473	<.001	.008	3	2
LUNG_SCLC	OR8B8 →	+0.062	+5.029	<.001	.006	3	2
BLOOD_Leukemia	OR2T12 →	+0.010	+2.536	.005	.009	3	2
BLOOD_Leukemia	DNAAF6 →	+0.023	+2.432	.001	.006	3	2
BREAST	KRTAP10-3 →	+0.050	+4.963	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 848 associations by consensus.

HAUS2 by MYOF expression — LARGE_INTESTINE

Explore this box plot interactively →