MYOD1

Across TCGA patient cohorts, MYOD1 mutation is significantly associated with the RNA expression of many other genes, with 1,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOD1-associated genes across cancer lineages are H2AZ1, TIMM22, and RAD51. Each is linked with MYOD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOD1-to-partner and partner-to-MYOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AZ1 grouped by MYOD1-low versus MYOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOD1→partner) and Y-score (partner→MYOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AZ1 →	+0.560	+1.797	.003	.008	3	3
UCEC	TIMM22 →	+0.405	+2.716	<.001	<.001	3	3
UCEC	RAD51 →	+0.645	+2.180	.001	.002	3	3
UCEC	GTSE1 →	+0.740	+2.338	<.001	.003	3	3
UCEC	WDR76 →	+0.660	+3.638	.001	.001	3	3
UCEC	CEP78 →	+0.513	+2.939	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,212 associations by consensus.

H2AZ1 by MYOD1 expression — UCEC

Explore this box plot interactively →