MYOD1

Across TCGA cell cohorts, MYOD1 mutation is significantly associated with the mutation status of many other genes, with 3,110 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYOD1-associated genes across cancer lineages are IRS1, CAND2, and STAG1. Each is linked with MYOD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYOD1-to-partner and partner-to-MYOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by MYOD1-low versus MYOD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOD1→partner) and Y-score (partner→MYOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IRS1 →	+1.584	+2.769	.008	.008	1	5
LUNG_SCLC	CAND2 →	+5.502	+5.502	.003	.003	1	4
LUNG_SCLC	STAG1 →	+4.502	+5.066	.007	.007	1	4
BLOOD_Lymphoma	TOP3A →	+4.014	+4.969	.008	.008	1	4
LUNG_SCLC	KLHL40 →	+5.502	+5.502	.003	.003	1	3
LUNG_SCLC	RCSD1 →	+5.502	+5.502	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,110 associations by consensus.

IRS1 by MYOD1 expression — LARGE_INTESTINE

Explore this box plot interactively →