MYOCD

Across TCGA patient cohorts, MYOCD mutation is significantly associated with the RNA expression of many other genes, with 6,084 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOCD-associated genes across cancer lineages are NCAPH, RAN, and SKA1. Each is linked with MYOCD in more than 3 cancer types. Because this analysis shows association rather than direction, both MYOCD-to-partner and partner-to-MYOCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPH grouped by MYOCD-low versus MYOCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOCD→partner) and Y-score (partner→MYOCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	+0.509	+1.284	.001	.001	3	4
UCEC	RAN →	+0.357	+1.748	.002	<.001	3	4
UCEC	SKA1 →	+0.746	+2.046	<.001	<.001	3	4
UCEC	PBK →	+0.740	+1.873	<.001	<.001	3	4
UCEC	MRTO4 →	+0.361	+1.862	<.001	<.001	3	4
LGG	MIR6738 →	+0.476	+3.511	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,084 associations by consensus.

NCAPH by MYOCD expression — UCEC

Explore this box plot interactively →