MYOCD

Across TCGA cell cohorts, MYOCD mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MYOCD-associated genes across cancer lineages are H2BC1, H2AC1, and PABPC1L2B. Each is linked with MYOCD in more than 1 cancer types. Because this analysis shows association rather than direction, both MYOCD-to-partner and partner-to-MYOCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by MYOCD-low versus MYOCD-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOCD→partner) and Y-score (partner→MYOCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
BLOOD_Myeloma	PABPC1L2B →	+0.006	+4.807	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR8B12 →	+0.054	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR8A1 →	+0.447	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10D3 →	+0.119	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

H2BC1 by MYOCD expression — SOFT_TISSUE

Explore this box plot interactively →