MYOC

Across TCGA patient cohorts, MYOC mutation is significantly associated with the RNA expression of many other genes, with 1,026 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYOC-associated genes across cancer lineages are RNU6-467P, RNU6-622P, and SGTA. Each is linked with MYOC in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOC-to-partner and partner-to-MYOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-467P grouped by MYOC-low versus MYOC-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOC→partner) and Y-score (partner→MYOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-467P →	+0.332	+5.321	<.001	.002	3	3
LGG	RNU6-622P →	+0.378	+7.977	<.001	.007	3	2
UCEC	SGTA →	+0.425	+3.268	.003	.008	3	2
UCEC	FARSB →	+0.406	+2.595	.004	.005	3	2
UCEC	MRPS15 →	+0.539	+2.828	<.001	.001	3	2
UCEC	EEF2KMT →	+0.454	+3.330	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,026 associations by consensus.

RNU6-467P by MYOC expression — LUSC

Explore this box plot interactively →