MYOC

Across TCGA patient cohorts, MYOC mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible MYOC-associated genes across cancer lineages are ATM, EGFR, and IRS1. Each is linked with MYOC in more than 2 cancer types. Because this analysis shows association rather than direction, both MYOC-to-partner and partner-to-MYOC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYOC-low versus MYOC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYOC→partner) and Y-score (partner→MYOC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.789	-3.321	<.001	.010	3	3
SKCM	EGFR →	+0.201	+3.000	.004	.034	3	2
SKCM	IRS1 →	+0.184	+2.321	.005	.033	3	2
SKCM	MIG-6 →	+0.271	+2.195	<.001	.032	3	2
SKCM	mTOR_pS2448 →	-0.168	-3.000	.032	.034	3	2
SKCM	Src_pY527 →	-0.372	-3.000	.045	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ATM by MYOC expression — UCEC

Explore this box plot interactively →