MYO7A

Across TCGA patient cohorts, MYO7A mutation is significantly associated with the RNA expression of many other genes, with 7,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO7A-associated genes across cancer lineages are ITPK1, TSNAXIP1, and PUS3. Each is linked with MYO7A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO7A-to-partner and partner-to-MYO7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITPK1 grouped by MYO7A-low versus MYO7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO7A→partner) and Y-score (partner→MYO7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITPK1 →	+0.256	+1.617	.002	.002	3	4
UCEC	TSNAXIP1 →	-0.459	-1.836	.004	.001	3	4
LUSC	PUS3 →	+0.326	+2.011	.002	.005	3	4
UCEC	AKR1A1 →	+0.204	+1.368	.003	.001	3	4
COAD	CYSTM1 →	+0.430	+2.873	<.001	.001	3	4
UCEC	GLRX5 →	+0.300	+1.369	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,712 associations by consensus.

ITPK1 by MYO7A expression — UCEC

Explore this box plot interactively →