MYO7A

Across TCGA patient cohorts, MYO7A mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO7A-associated genes across cancer lineages are ATM, p62 Lck ligand, and TIGAR. Each is linked with MYO7A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO7A-to-partner and partner-to-MYO7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYO7A-low versus MYO7A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO7A→partner) and Y-score (partner→MYO7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.565	-1.357	<.001	<.001	3	4
LUSC	p62 Lck ligand →	+0.544	+2.009	.021	.018	3	3
SKCM	TIGAR →	+0.077	+1.296	.044	.028	3	3
SKCM	4E-BP1_pS65 →	+0.151	+2.807	.009	.002	3	3
UCEC	Notch1 →	+0.118	+1.115	<.001	.004	3	3
UCEC	PCNA →	+0.170	+1.643	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

ATM by MYO7A expression — UCEC

Explore this box plot interactively →