MYO7A

Across TCGA cell cohorts, MYO7A mutation is significantly associated with the RNA expression of many other genes, with 1,584 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO7A-associated genes across cancer lineages are LGI3, FNBP1L, and KRT3. Each is linked with MYO7A in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO7A-to-partner and partner-to-MYO7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI3 grouped by MYO7A-low versus MYO7A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO7A→partner) and Y-score (partner→MYO7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI3 →	+0.077	+1.906	.001	.005	3	3
LARGE_INTESTINE	FNBP1L →	+0.592	+3.409	<.001	<.001	3	3
BLOOD_Myeloma	KRT3 →	+0.064	+3.906	.004	.009	3	2
SOFT_TISSUE	ODF3 →	+0.017	+4.652	<.001	<.001	3	2
LARGE_INTESTINE	TMEM125 →	+1.001	+3.321	.003	.002	3	2
BLOOD_Leukemia	SCML2 →	+1.234	+2.837	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,584 associations by consensus.

LGI3 by MYO7A expression — BLOOD_Leukemia

Explore this box plot interactively →