Across TCGA cell cohorts, MYO6 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO6-associated genes across cancer lineages are IL1F10, TLE7, and CYP11B2. Each is linked with MYO6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO6-to-partner and partner-to-MYO6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO6→partner) and Y-score (partner→MYO6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	IL1F10 →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	TLE7 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	CYP11B2 →	+0.005	+5.247	<.001	.001	3	1
LARGE_INTESTINE	TNFSF18 →	+0.376	+3.648	<.001	.002	3	1
LARGE_INTESTINE	LONRF2 →	+0.549	+3.464	<.001	.004	3	1
LARGE_INTESTINE	ABCG4 →	+0.361	+3.451	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

MYO6 survival (RNA) · tumor vs normal (RNA) · all MYO6 data types