Across TCGA pan-cancer cohorts, MYO5BP1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MYO5BP1’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where MYO5BP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MYO5BP1 is over-expressed in tumor.
STAD, BRCA, and BLCA are the cancer types where MYO5BP1 tumor–normal differential expression is most reproducible.