MYO5B

Across TCGA pan-cancer cohorts, MYO5B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MYO5B data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MYO5B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MYO5B expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where MYO5B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.908	.010	30	view →
LUAD	OS	Tertile	All	0.524	1.000	.001	20	view →
CCRCC	DFS	Median	All	0.896	0.700	<.001	18	view →
GBM	DFS	Tertile	All	0.274	0.519	.013	2	view →
UCEC	OS	Tertile	All	1.000	0.931	.045	2	view →
HNSC	DFS	Quartile	III,IV	0.865	0.662	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MYO5B–COAD (DFS)

Open the COAD breakdown →