MYO5B

Across TCGA patient cohorts, MYO5B mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO5B-associated genes across cancer lineages are MEK1, INPP4B, and YB-1. Each is linked with MYO5B in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO5B-to-partner and partner-to-MYO5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MYO5B-low versus MYO5B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5B→partner) and Y-score (partner→MYO5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEK1 →	+0.238	+1.847	.008	.006	3	3
COAD	INPP4B →	-0.431	-3.169	.007	.017	3	3
LUAD	YB-1 →	+0.492	+3.169	.006	.019	3	2
UCEC	FOXO3a_pS318_S321 →	-0.090	-1.575	.014	.008	3	2
UCEC	Notch1 →	+0.157	+1.637	<.001	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.469	-1.419	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

MEK1 by MYO5B expression — SKCM

Explore this box plot interactively →