MYO5B

Across TCGA cell cohorts, MYO5B mutation is significantly associated with the RNA expression of many other genes, with 257 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO5B-associated genes across cancer lineages are MOG, GALR3, and ARMC1. Each is linked with MYO5B in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO5B-to-partner and partner-to-MYO5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MOG grouped by MYO5B-low versus MYO5B-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5B→partner) and Y-score (partner→MYO5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MOG →	+0.429	+3.807	<.001	.006	3	2
SKIN	GALR3 →	+0.056	+2.765	.005	.006	3	2
LARGE_INTESTINE	ARMC1 →	+0.387	+3.067	.007	.009	3	2
LARGE_INTESTINE	SH3GL2 →	+1.202	+3.502	<.001	.001	3	2
LARGE_INTESTINE	HMGN4 →	+0.553	+3.502	.001	.001	3	2
BLOOD_Leukemia	SFTPC →	+0.048	+2.240	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 257 associations by consensus.

MOG by MYO5B expression — SOFT_TISSUE

Explore this box plot interactively →