Across TCGA patient cohorts, MYO5A mutation is significantly associated with the RNA expression of many other genes, with 6,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO5A-associated genes across cancer lineages are MTHFD2, MARCHF5, and NUSAP1. Each is linked with MYO5A in more than 5 cancer types. Because this analysis shows association rather than direction, both MYO5A-to-partner and partner-to-MYO5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5A→partner) and Y-score (partner→MYO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MTHFD2 →	+0.646	+3.195	.001	.009	3	6
UCEC	MARCHF5 →	+0.369	+1.593	<.001	<.001	3	5
UCEC	NUSAP1 →	+0.599	+1.684	<.001	<.001	3	5
UCEC	KNL1 →	+0.525	+1.426	<.001	<.001	3	5
STAD	MTFR2 →	+0.668	+3.195	.004	.009	3	5
UCEC	NUS1 →	+0.325	+1.209	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,133 associations by consensus.

Exploration

MYO5A survival (RNA) · tumor vs normal (RNA) · all MYO5A data types