Across TCGA patient cohorts, MYO5A mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO5A-associated genes across cancer lineages are ACC1, 4E-BP1, and ASNS. Each is linked with MYO5A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO5A-to-partner and partner-to-MYO5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5A→partner) and Y-score (partner→MYO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.238	+1.598	.010	.004	3	4
UCEC	4E-BP1 →	+0.246	+2.662	<.001	<.001	3	4
UCEC	ASNS →	+0.307	+1.295	<.001	.008	3	3
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.509	<.001	<.001	3	3
STAD	FASN →	+0.542	+2.823	.003	.034	3	2
STAD	HSP70 →	-0.582	-2.321	.010	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Exploration

MYO5A survival (RNA) · tumor vs normal (RNA) · all MYO5A data types